Br.J Pharmacol 2000;131(2):169-172. Li, W. Q., Dehnade, F., and Zafarullah, M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. 2004;40(6):1216-1222. Oncogene 2004;23:9247-58. View abstract. View abstract. View abstract. Contraception 2003;68(3):219-223. Park, E. J., Jeon, C. H., Ko, G., Kim, J., and Sohn, D. H. Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. Chen, D., Nie, M., Fan, M. W., and Bian, Z. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults. View abstract. 2010;32(2):209-214. View abstract. 2019;33(3):561-570. 2004;22(6):609-612. View abstract. Fiziol.Zh. Hallajzadeh J, Milajerdi A, Kolahdooz F, Amirani E, Mirzaei H, Asemi Z. [Epub ahead of print] View abstract. Lin, R., Chen, X., Li, W., Han, Y., Liu, P., and Pi, R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. 2008;46(3):920-928. Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Mol.Reprod.Dev 2011;78(2):116-123. Thapliyal R, Maru GB. View abstract. Biochem.Biophys.Res Commun. Early research suggests that taking curcumin, a chemical found in turmeric, might improve symptoms of long-term swelling of the eye. Mechanisms of action Preventing gas. Pungcharoenkul, K. and Thongnopnua, P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. View abstract. View abstract. View abstract. Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., and Appendino, G. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Allergic contact dermatitis from curcumin (turmeric). View abstract. 2-18-2005;327(3):866-870. 2008;9(4):243-250. Chem.Biol.Interact. Hu, Y., Du, Q., and Tang, Q. Phytother Res 2019;33(11):2989-95. doi: 10.1002/ptr.6477. View abstract. Nayak, S. and Sashidhar, R. B. Metabolic intervention of aflatoxin B1 toxicity by curcumin. Lab Invest 2010;90(1):104-115. Indigestion (dyspepsia). The effects of curcumin on depressive-like behaviors in mice. View abstract. Pharm Biol. View abstract. October 7, 2020. View abstract. View abstract. Effects of curcumin on Cryptosporidium parvum in vitro. 7-15-2009;124(2):189-196. Chem.Pharm Bull. Complement Ther Med. A novel highly bioavailable curcumin formulation improves symptoms and diagnostic indicators in rheumatoid arthritis patients: A randomized, double-blind, placebo-controlled, two-dose, three-arm, and parallel-group study. how the brain works and what happens when a person uses drugs, interactive chart featuring Monitoring the Future data from 2016 to present, NIDA's Step by Step Guide for Teens and Young Adults, Mind Over Matter Teaching Guide and Series: Inhalants, United States Adolescent Substance Abuse Facts (National and State Data), Cough and Cold Medicine (DXM and Codeine Syrup), Prescription Stimulant Medications (Amphetamines), Tobacco, Nicotine, & Vaping (E-Cigarettes), Viral Infections (HIV, Hepatitis) and Drug Use, U.S. Department of Health and Human Services, altered perception (changes in awareness of objects and conditions), psychosis (feeling detached from reality), hallucinations (seeing or hearing things that aren’t there). Efficacy and safety of Meriva, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. 2-23-2005;53(4):959-963. 2019;33(2):370-378. Teichmann, A., Heuschkel, S., Jacobi, U., Presse, G., Neubert, R. H., Sterry, W., and Lademann, J. Saadipoor A, Razzaghdoust A, Simforoosh N, et al. Abstract 316. Gonda, R., Tomoda, M., Shimizu, N., and Kanari, M. Characterization of polysaccharides having activity on the reticuloendothelial system from the rhizome of Curcuma longa. View abstract. Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. View abstract. Turmeric might slow blood clotting. Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., and Hsieh, C. Y. View abstract. Rastogi, M., Ojha, R. P., Rajamanickam, G. V., Agrawal, A., Aggarwal, A., and Dubey, G. P. Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. View abstract. 2006;35(4):481-489. J Contemp Dent Pract. View abstract. Mitchell TM. Curcuminoid content and safety-related markers of quality of turmeric dietary supplements sold in an urban retail marketplace in the United States. J Med Assoc Thai 2012;95 Suppl 1:S51-8. Blood 1-8-2009;113(2):462-469. Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Early research suggests that taking a product containing turmeric and Tinospora cordifolia can reduce bacteria levels, improve wound healing, and reduce liver toxicity caused by antituberculosis therapy in people with tuberculosis who are receiving antituberculosis therapy. J Agric.Food Chem. Ahmed, T., Enam, S. A., and Gilani, A. H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biofactors 2002;16(1-2):29-43. View abstract. View abstract. Support Care Cancer. [The effect of curcumin on bleomycin-induced pulmonary fibrosis in rats]. View abstract. Yu, Z. F., Kong, L. D., and Chen, Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. Khonche A, Biglarian O, Panahi Y, et al. J Ethnopharmacol. 2008;29(5):555-563. View abstract. The resulting health effects can be unpredictable and dangerous. Mani, H., Sidhu, G. S., Kumari, R., Gaddipati, J. P., Seth, P., and Maheshwari, R. K. Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. Springhouse, PA: Springhouse Corp., 1999. Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., and Cole, G. M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. View abstract. J Contemp.Dent Pract. 2008;9 Suppl 2:S13. Some of these adults showed signs of mild mental decline before taking curcumin. Gen.Physiol Biophys. Allam, G. Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni. View abstract. View abstract. Do a good deed and kill the weed; Put the Stash in the Trash. Rahmani S, Asgary S, Askari G, et al. Nahrung 2003;47(4):261-264. Int.J Radiat.Oncol.Biol.Phys. 2008;29(5):717-721. View abstract. He, Z. Y., Shi, C. B., Wen, H., Li, F. L., Wang, B. L., and Wang, J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Allen, S. W., Mueller, L., Williams, S. N., Quattrochi, L. C., and Raucy, J. Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Bourne, K. Z., Bourne, N., Reising, S. F., and Stanberry, L. R. Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. Effects of Curcuma Longa on proliferation of cultured bovine smooth muscle cells and on expression of low density lipoprotein receptor in cells. Ghaffari A, Rafraf M, Navekar R, Sepehri B, Asghari-Jafarabadi M, Ghavami SM. Rafatullah, S., Tariq, M., Al Yahya, M. A., Mossa, J. S., and Ageel, A. M. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. View abstract. View abstract. Endocrinology 2008;149(7):3549-3558. Do not use different forms of turmeric (pills, liquids, and others) at the same time or you could have an overdose. Mol Nutr Food Res. Eur J Phys Rehabil Med. Clinical Evaluation of a herbal product (Rhulief) in the management of knee osteoarthritis. View abstract. Get the latest information from CDC ( | NIH Resources | NIDA Resources, Also known as: Black Mamba, Bliss, Bombay Blue, Fake Weed, Genie, K2, Yucatan Fire, and Zohai, Spice is a mix of herbs (shredded plant material) and laboratory-made chemicals with mind-altering effects. 2006;290(1-2):87-96. View abstract. View abstract. View abstract. Acute liver injury following turmeric use in Tuscany: an analysis of the Italian Phytovigilance database and systematic review of case reports. Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report. View abstract. Acta Trop. View abstract. Drug Metab Dispos. View abstract. 8-14-2008;14(30):4753-4762. 2016 Sep;30(9):1540-8. [Determination of chemical constituents of the volatile oil from Curcuma longa by gas chromatography-mass spectrometry]. A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori). CONDITIONS OF USE AND IMPORTANT INFORMATION: Hot Peppers, sweet peppers, spicy stuff, and more. A. It is important to protect your own mental health and not put yourself in situations where drugs are being used. Khayat S, Fanaei H, Kherikhah M, Moghadam ZB, Kasaeian A, Javadimehr M. Curcumin attenuates severity of premenstrual syndrome symptoms: a randomized, double-blind, placebo-controlled trial. View abstract. Cancer Biol.Ther. Wu, J. C., Lai, C. S., Badmaev, V., Nagabhushanam, K., Ho, C. T., and Pan, M. H. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Eur.J Pharmacol 7-25-2005;518(1):40-46. 2018 Jun;17(3):461-466. View abstract. Vascul.Pharmacol 2007;47(1):25-30. View abstract. View abstract. 2011;347(1-2):1-11. Kulkarni RR, Patki PS, Jog VP, et al. Surh YJ. Nutrition 2009;25(9):973-974. Diabetes. Diabetes Care 2012;35(11):2121-2127. 2005;12(6-7):445-452. Mrudula, T., Suryanarayana, P., Srinivas, P. N., and Reddy, G. B. View abstract. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). 2002;33(3):137-145. Ganta, S., Devalapally, H., and Amiji, M. Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation. J Agric.Food Chem. Ataei-Almanghadim K, Farshbaf-Khalili A, Ostadrahimic AL, et al. Rasyid A, Rahman AR, Jaalam K, Lelo A. Aliment.Pharmacol Ther. Vanilla Bean [ORAC 122,400] 2016;90(2):69-78. 2009;20(1):19-23. Curcumin has anti-inflammatory properties, making it a potential treatment for a number of health conditions, including reduced pain and increased ease of movement in people with osteoarthritis. 2018 Apr;109(2):88-94. Kiec-Swierczynska, M. and Krecisz, B. Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats. Contact Dermatitis 1998;39(1):30-31. View abstract. 1990;29(1):25-34. DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed. View abstract. Acta Pharmacol Sin. 2005;5(5):849-856. However, it's not yet known if this formula, or turmeric alone, reduces the risk of prostate cancer progression or recurrence. View abstract. View abstract. Skin damage caused by radiation therapy (radiation dermatitis). ):242-252 105 ( 8 ):1210-1217 curcumin, a diabetes Care 2012 ; (. H. F. and Shen, L., Song, T. X Know about Vitamin B12 Deficiency other spices... They also help control swelling and inflammation in diabetes, Singh AK, Asthana OP, al! Escherichia coli from Chinese medicine monomers sanmukhani j, Patel T, et al of artemisinin/artesunate inhibitors... 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