I don't abuse my friends and family, my anxiety is significantly lessened, and I can act normally in social situations. NOTE: SUSTAINED RELEASE flush free niacin is not what you want as it ACTUALLY can accumulate in your system and can do some liver stuff if too much. I’m also suffering from pure O OCD and just started Memantine today. Additionally, it’s a non-essential amino acid which means your body can synthesize it when necessary.. Glutamate is the most abundant neurotransmitter in the brain and central nervous system. Background: Dysregulation of glutamate is implicated in the pathogenesis of obsessive-compulsive disorder (OCD). I just started it today. I'm writing a quick post to try and convince people to try what I did. Treating Obsessive-Compulsive Disorder Symptoms; Memantine can help with decreasing the symptoms of OCD but not on its own. I would say it's helped and definitely worth a try. i would love to try CBD but unfortunately can't because I live in a sober house. Chills out my mind and relieves the muscle tension that develops when I ruminate negative thoughts before bed. This article was initially published in the Summer 2013 edition of the OCD Newsletter. Several case reports and two recent open-label case series suggest that the addition of memantine to standard medication therapy can benefit both children and adults with OCD. Towards New Medications for Refractory OCD. The prim … A Meta-Analysis of Memantine for Depression J Alzheimers Dis. Self‐reported users experiences posted on reddit.com were recorded and sorted using representative keywords. I have severe form of OCD. Memantine appears to work by regulating the activity of glutamate, one of the brain's specialized messenger chemicals, which may play a role in OCD. Started at 600mg am 600 mg p.m went up to 1800 mg am, 1800 mg pm. It was bad enough I felt it no longer wise to drive a car. Common Questions and Answers about Memantine and ocd. The analysis included double-blind, randomized, placebo-controlled trials of memantine in … 6) May Decrease Symptoms of Obsessive-Compulsive Disorder (OCD) According to some studies, memantine has shown some potential when used in addition to first-line treatments for OCD . Read More. Several case reports and two recent open-label case series suggest that the addition of memantine to standard medication therapy can benefit both children and adults with OCD. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. Most of the times are an approximation. Niacin is prescribed by doctors at 2000 mg per day in divided doses to help people control cholesterol that don't want to use statins, so it is a very safe supplement. If anyone has information on or experience with any of the above medications, would you please share that with me? Current psychotherapy and medication treatments for OCD can be of help to many who suffer from the disorder. Worked well for about a month and now I don't feel it as much...thinking off cycling off of it for a week or two and resetting. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this backfired obviously. namenda. Chantix stopped that too. If one does not mind waiting a few hours for the effects to be felt, and due to the pain involved with intramuscular injection, I believe … We conducted a systematic review and meta-analysis on whether memantine was beneficial for the treatment of depressive symptoms in major depressive disorder (MDD) and bipolar disorder (BD). Hello. Discussion of nootropics and cognitive enhancers. And one day I realized....I haven't been doing my rituals. I just bought 10 grams primarily for a reduction in OCD symptoms. I agree with you about that some may like and others may not like the side effects, it was a mixed 50/50 like/dislike for me to be honest. Current psychotherapy and medication treatments for OCD can be of help to many who suffer from the disorder. OCD patients also have higher plasma levels of dehydroepiandrosterone-sulfate ... Memantine (5-20mg) . Four to five symptom clusters or OCD types are common, and each has its associated obsessions and compulsions [6, 7, 8]:Checking: Forbidden or instrusive thoughts (aggressive, sexual, religious, or somatic obsessions) and checking compulsions; Instrusive Thoughts: Obsessions with no clear compulsion (may involve … Memantine is an N-methyl-D-aspartate receptor antagonist, approved for the treatment of Alzheimer’s dementia in a number of countries. 11 In another case–control study, memantine was found to be effective as a glutamatergic‐augmenting agent in severe OCD. Unlike benzos you don't feel slower on it, you just feel this sort of "thick"/"slowed" feeling in your mind sort of like you're too tired to care about being anxious (like "I could be worried about that but what's the point it won't do anything") but at the same time you don't actually feel mentally tired. After reading about memantine, it seems promising. by Christopher Pittenger, MD, PhD, & Wayne Goodman, MD. In regards to your experiences, would you agree this has anti obsessive properties, and should it be worth the risk of trying. I dry vaped it directly on coils for an oil vape, but that is likely not great long-term so vape wise you should learn to mix solutions and get a good fluid-based vape. Its also pretty stimulating for me and I tend to act a bit strange if I let myself loose. I got memantine last fall under the hope that it could improve the effects of lisdexamfetamine (it seems to prolong them in a really smooth way) & help TR OCD, and she's familiar with memantine as she used to work as a Psych for a nursing home and used it a lot. This will gradually be increased over the following few weeks. I am currently on vyvanse which helps the OCD somewhat (can make it worse though), gabapentin 600mg 3x a day, propanalol 20mg 3x, baclofen 20mg 3x, lamictal 100mg, and melatonin for sleep. An open-label st… I know this is counterintuitive to do something uncomfortable to get relief...but when you know its coming and tell yourself that the flushing and itching will stop in 30-40 minutes and IS COMPLETELY normal, it really helps. I read some of your previous posts on it I suffer with over self consciousness too, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425334/. Another drug, the N-methyl-d-aspartate antagonist memantine, has recently been tested in the treatment of OCD. Also seems to potentiate adderall and other meds. OCD has become a very fascinating illness to me, and I've been bothering my psychiatrist friends for a while with stories about their complex patients. It involves rumination, negative thought loops, POCD, and just severe uncomfortably in my head and social situations. Press question mark to learn the rest of the keyboard shortcuts. Should have it tomorrow or the next day and might have some input then. The present study investigates the effect of fluoxetine and memantine alone and in combination in a mouse model of compulsive behavior. Researchers examined whether adjunctive gabapentin or memantine and standard treatment with a selective serotonin-reuptake inhibitor (SSRI) might lead to further improvements in patients with OCD. Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Additionally, do you recommend your patients undergo CBT/ERP? Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA).Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. I also have very severe migraines, and was not aware Memantine could treat it. Compulsivity is a cross-disorder trait underlying phenotypically distinct psychiatric disorders that emerge in childhood or adolescence. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. 90% of my anxiety is linked to this. But have OCD. Context At the time of dosing: -I have depression, anxiety, OCD, and ADHD.-My mental health had been improving, but it back-slid over the winter break. This reddit thread has some great resources to find a trust worthy vendor for the isolate (crystalline powder). Brand names. Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Request PDF | On Aug 10, 2015, Scott R Pekrul and others published Memantine Augmentation in a Down's Syndrome Adolescent with Treatment- Resistant Obsessive-Compulsive Disorder | … Self‐reported users experiences posted on reddit… In a randomized double-blind placebo-controlled study of memantine combined with fluoxetine published by Ghaleiha et al. Treating Bipolar Disorder User Reviews for Memantine. The only problem is that pretty much all of the pure-extracts are fake or low quality. I am a chronic suffer of Severe OCD, and have read numerous of studies of Memantine being effective for treatment resistant OCD. Good to hear! Obsessive-compulsive disorder (OCD) is a mental illness that affects almost 3% of Americans. When the flush wears off, my mind feels just like I just got home from the gym and just sat down in my favorite chair....with that calm, relaxed feeling. ... Reddit; Most popular articles. This reddit thread has some great resources to find a trust worthy vendor for the isolate (crystalline powder). It’s basically a mental condition where an individual experiences bothersome, intrusive, and worrisome thoughts that elicit a feeling of discomfort and/or fear that often leads to obsessive-compulsive behaviors. Method A Google Trends search was used to highlight reddit.com as a major source of social discussions about memantine. Take one dose every day, at the same time of day each day. 1. Health food stores and Amazon are the place for this. A second drug that is already available and affects how neurons respond to glutamate is memantine (Namenda®). Also it is indeed hard to describe how it feels like unless youve been on it yourself yes :). Moreover, augmentation therapy with amantadine and memantine, another glutamate modulator, was used in open‐label studies in OCD patients who had failed to respond properly to SRI with promising results. It may help short term, but long term I worry that it can aggravate...folks sometimes "pick" and obsess on amphetamines...especially the longer acting Meth versions. Reddit; Wechat; Abstract. I am desperate. Thanks so much. The association of OCD-schizotypal comorbidity with the beneficial effect of memantine is noteworthy in view of a pertinence of glutamatergic dysfunction in both OCD and schizophrenia spectrum disorders . Some trials even reported a 100% response! It’s pretty surprising when I take a look through the community though I’ve never tried it myself. Some places refer to Niacinimide as Niacin and it is not the same. Too many people are taking these crazy 10mg doses that burn them in the long run and paradoxically don't work as well for sleep as the 1 mg liquid. Antipsychotics were one of the first medications to be tried for treatment of OCD. Any papers you can share with me? Interesting. I'm only a few days in but will let you know regarding things like intrusive thoughts, physical compulsions and anxiety. Obsessive Compulsive Disorder In one double-blind, randomized, placebo-controlled human study of 40 adults suffering from OCD, it was found that memantine, when used in concert with the prescription drugs already taken by the patients, led to a statistical improvement in OCD symptoms in comparison to the prescription drugs alone. Aim. 10-40 mg helps with OCD issues imo altho im not SUPER OCD. ey guys, long time viewer, first time poster. Niacin, 100 to 200 mg. You want the kind that makes you flush and itch. I've read reports on reddit and some journals that memantine can help OCD. I am currently on vyvanse which helps the OCD somewhat (can make it worse though), gabapentin 600mg 3x a day, propanalol 20mg 3x, baclofen 20mg 3x, lamictal 100mg, and melatonin for sleep. It's hard to explain. Also known as: Namenda, Namenda XR Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. It can work the opposite too though, as I once got stuck into a 12 hour long whack off session. PURPOSE: Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist currently used for moderate-to-severe Alzheimer's disease. Of all the neurotransmitters, glutamate is considered the most critical for healthy brain function.
It isn’t a cure (there is no cure for Alzheimer’s or related dementias) but studies have shown memantine treats symptoms by improving memory, awareness, and concentration. I personally found it had some weird effects on my vision and mood. Press question mark to learn the rest of the keyboard shortcuts. Studies show that when it’s used alongside other conventional medications of OCD, the drugs can have a much better impact. Consistently, glutamate-modulating agents, such as riluzole and memantine have been used in OCD treatment. CBD's primary mechanism of action is upregulating 5HT-1A receptors (subset that among many things increases social behavior and partially mediates the relief/pleasure from social interaction (along with a bunch of other receptors obviously), increasing natural cannabinoids by slowing the enzyme that metabolizes them, by positively modulating opioid receptors (very slightly), and finally may directly modulate calcium signalling (responsible for excitation of neurons), reducing excessive flow of calcium into neurons. NAC (500mg-2g daily) . think of a healing plant or healing open wound. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. -L theanine....can take shitloads of it if I'm having a bad moment.... and haven't managed to fuck myself up on it and haven't heard of anybody doing so. You basically either mix it into an oil (preferably coconut) and take it orally or vaporize it on it's own (never try to vaporize oil, vape fluid is propylene glycol). Provigil has been used off label for years to help with cocaine cravings (obsession). Another drug, the N-methyl-d-aspartate antagonist memantine, has recently been tested in the treatment of OCD. Do you think my psychiatrist who I have a good relationship with will let me do it. Most particularly compulsive behaviors. Can't really recommend Klonopin for anybody on a daily basis though. There are very few if any well designed studies on antipsychotic monotherapy for OCD. Memantine will definitely slow down racing, uncontrolled thoughts, though you may or may not like the side-effects. I had success with memantine as well but discontinued it for other reasons but I'm wanting to start again with the same issues you have. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. In the meantime, although, I don't have clinically diagnosed OCD, I have no doubt I am on the spectrum. I'm in need of help, please. I was able to mix 50 mg of memantine hydrochloride into 1 ml of distilled water only after applying light heat to increase solubility. And how long did it take to work for your OCD? Hi. I've tried SSRIs, almost all of them, and hated them. I'm curious if smoking marijuana daily had an effect on the brain fog and positive effects of memantine. Hi. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. It does not however make you feel high; there is a slight "shift" in perception but in no way are you intoxicated or slowed down. I'm on 40mg vyvanse and 5mg memantine, so far it's good but worried if I will need to see psych soon to increase my dose. Outstanding stack for higher libido (and bigger balls) 40 best ways to increase DHT (2020 update) 20 aromatase inhibiting foods that will lower your estrogen after the first bite; Inhibit Aromatase: 31 Potent Supplements; 60 … Types. Walmart, Walgreens and grocery stores do not carry good old regular Niacin I think because they are scared to death people will take it without knowing about the harmless flush and thus send themselves to the hospital thinking they are having a reaction. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. Was wondering if asking my doctor for memantine would be a good idea. 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