Low quality posts will be removed. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. Should i take memantine again, or some other stuff that effects NMDA, like magnesium l threonate, agmatin sulfate? Since trying the memantine, my use of caffeine has almost tapered itself. What I didn't expect was that I would no longer need the Adderall. Memantine may be useful for treating substance abuse and dependence. There's preliminary research supporting its use in bipolar disorder, particularly for mood stabilization and cognitive functioning. Results From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. I thought I would get the anoxiolysis without sedation with this combo. Any help is apriciated. memantine. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. Feel free to share yours. In this case, you're likely masking it. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. Tried a looot of noots, 99 percent of them have no effect. In a previous pre-clinical … Tl dr: most noots not working, memantine 2mg sucked CD out of me. Another good thing is it doesnt give me brain fog i was scared of. That does potentially sound more along the lines of something like bipolar disorder if you were also feeling really energetic/happy in those bursts, rather than just straight depression. A sub for discussing all uses of Memantine, from therapeutic to recreational. Zombie like, with thousand yard stare dreaming of suicide. 6 days after first dose i noticed im less depressed. One interesting memantine side effect includes higher libido. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. It's just something you might want to bear in mind. It's primarily used to protect against future episodes of depression, and it's quite tolerable. psychomotor retardation is horrible stinky crap. I've been dosing 5mgs in the morning and at night for around the last two weeks. “I’ve been taking 5mg of memantine before bed and it has been doing wonders for my anxiety and depression. I am either going to add memantine to this combo or take it alone. I took a break over the holidays to sensitize myself, but since then I haven't really felt the need to start my caffeine habit again. What should I do? The memantine dosage will differ based on the use case. Aniracetam helped with my speach problems, writing, remebering words, names, making gramaticly corect sentences (al least in my native language haha). Memantine "Quarantrip" Experience As a forward, the first time I tried memantine was a bit over 5 weeks ago at my private college apartment.The dosage was 73mg and the experience was enjoyable and unique. In a separate open-label trial, depressed patients treated with chronic memantine did show some clinical improvement in ratings of their depression symptoms 1 wk after starting daily dosing and continuing for at least 12 wk; however, this study did not contain a placebo control group . Antidepressant effects of nitrous oxide in these studies started within 2 h and lasted up to 1 week. Memantine increases cognitive effects dose-dependently in the absence of the AChE-I and the slope (in % correct on the 2-back WM test for 0–40 mg of memantine) of 0.08 is increased to 0.23 and 0.34 when adding donepezil 5 and 10 mg, respectively. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. Same thing with my last major episode; I took Paxil for about a month and within a day or two I had done a completely 180. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA). Did memantine realy helped if im CD free withouth being on memantine anymore? Then memantine is pulled into the channel to its binding site. Memantine Experiences and Anecdotals from the Internet. Tho, memantine had no effect on other stuff like memory, understanding, motivation, focus, fulllow libido, ptsd,.. memantine sidefects (only while im taking m.) : i feel like its throwing me into slight autism. Discussion and anecdotes are welcome! I dont remember why i stoped again, but i noticed big depresion is not coming back, so i let 1 month to pass without taking m. And im still CDFree. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. Memantine (Akatinol memantine), an agent that is approved in Germany for dementia syndrome, Parkinson's disease has significant antiglutamatergic and neuroprotective properties, may prove to have antidepressant properties in depressed patients. Memantine binds and inhibits NMDA receptors with low-to-moderate affinity, most effectively in states of excess glutamatergic activity (such as in substance use disorder). A bit of background, I'm a 24 year old male premed student. I'm not entirely sure why, but I'm an extremely rapid responder to SSRI's. Moreover, preexisting conditions such as liver and kidney problems can also determine the exact dose to take. This year was hardcore shity. I was on memantine around 2m. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. [157] Therapeutic doses (~10 mg) of memantine induced a mild altered state with cognitive stimulation and altered thought patterns with some parallels to low dose arylcyclohexylamines… Assortment of studies and abstracts — a mildly … 3. My moods don't rapidly shift from mania to depression or vice versa. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Memantine is great. Im also on cymbalta 30 mg(uper dose doesnt feel any different). Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Ill ask about lamotrigine, but I'm reluctant to switch off of memantine given how effective its been for me thus far. From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Like, im looking at world from inside and dont feel like interacting with people to much, like to observe more, movement of leaf, color on something, but not in a smart way, i dont conclude anything from observing, no numbers flying around me, that would be epic., also sometimes i feal like i cant move, i get scared im going catatonic so i move my body to prove myself im fine. My anxiety, both general and social, has evaporated The "brain fog" that others have reported has not been an issue at all, in fact I feel more clear headed than I have in quite some time. The drug, memantine, acts on the brain’s NMDA receptors – those known to play a role in treating depression. Vs Depression Mood Enhancer Vs Schizophrenia Tolerance Reset Mechanism of Action Experiential Effects Usage & Dosage Side Effects Risk Grade Conclusion Memantine Videos. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. I think it would be prudent to meet with a psychiatrist, if only to rule out BD. Almost all year i had no power to evan roll in bed, tho i was fighting it. As soon as I got it, I stupidly took a recreational dose of 50mg when the original reason I purchased it was to help with my gabapentin and eventually ativan taper. Has anybody had long term success with memantine? Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third or fourth day of dosing. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Both the research [18] and anecdotal reports [19] recount as much. I'm meeting with a psychiatrist in two days actually so I'll bring this up. Hi, i was taking around 2 mg of memantine every third or other day. Anxiety and stress are my two worst demons and memantine is much better supported as an anxiolytic than it is as a mood stabilizer. Store memantine at room temperature away from moisture and heat. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. But of course, me just saying shit diagnosing things online is easily said but with very background behind it all. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. From novel/alternative substances, to established medications. Larger-scale, randomized controlled trials are necessary before one … Tried a lot of antidepresants during past 10 years, i dont think they do much for me. Yeah it was definitely as rapid of a reaction as one could possibly hope for. Press question mark to learn the rest of the keyboard shortcuts. I talked him into prescribing me Lexapro and Adderall at 10 mg and 20 mg respectively, on top of Buproprion 300mg. Interesting. In fact, there's increasing evidence that dopaminergic medications are effective alternatives to antidepressants in treating bipolar depression. What is it about BD that makes SSRI's have such a rapid onset of effect? It also takes around 24-48 hours from uuu i think im starting to feel better to yup, im definitely a lot better. This is my experience with Memantine. Our study supports the hypothesis that drugs with antagonistic properties on the NMDA receptor, such as memantine, might be efficient in treatment of major depression. Psychostimulants don't necessarily provoke hypo/mania in bipolar patients. Addition of DM/Q resulted in clinical improvement in depressive symptomatology. So I have some liquid memantine. One of those downswings came around 4 months ago. Press J to jump to the feed. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Magnetic resonance … The severity of the condition will also influence how much Memantine to take. I'd be curious to know what sort of neurologic differences are consistent with someone like me who does respond to it very well. –Reddit user review “I’m still adjusting to 20mg, but I spent about 6 weeks at 10mg and I like memantine … Here is a very comprehensive article on the subject, https://psychedelicstoday.com/2018/09/08/rapid-depression-remission-therapeutic-bends-ketamine-assisted-psychotherapy/, o hey relevant to my interests as I've definitely anecdotally noticed difficulty with rapid cessation so it's nice to know there is clinical literature about it, i can't speak with any absolute certainty on whether it does or doesn't in all neurological substrates but i find that for my specific chemical imbalances, nmda antagonists tend to have the most effective and reliable effect profile necessary to make me feel as though I can function and not exist in a constant state of depression. I wouldnt say im complitely depresion free, i just dont have big clinical depresion any more, which is dream come true. Nitrous oxide (N2O, laughing gas) has shown early promise as a rapidly acting treatment for treatment-resistant major depression (1–3). I'm jealous of Memantine responders. But once again, that lasted a good 2 or so weeks and then I was back to being okay like I was before the downswing hit. By blocking NMDA receptors, mema… However, the memantine group averaged significantly greater improvement in scores on both the Montgomery-Åsberg Depression Rating Scale and the Apathy Evaluation Scale, according to the poster abstract. However, the molecular mechanisms underlying the antidepressive properties of memantine in animal and clinical studies still have not been fully explored. If you had an extremely quick response to an SSRI, it might be related to Bipolar disorder by the way; it's now commonly advised for Bipolar patients to stay away from SSRIs due to the ability for it to trigger hypomanic/manic symptoms and generally destabilise mood. I dont mind those sideefects too much, they are liveable, CD not so much. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. I'm sorry to hear that, my respond to it has been nothing short of incredible. Depression remission rates were 79.4% in the memantine group and 62.1% in the placebo group, which was not a statistically significant difference. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. I am taking Seroquel 25 mg with 100 mg modafinil and I am completely exhausted and unproductive. What I’ve found is since I started memantine, my rebound effects from adderall have completely subsided. My question is: How long do I need to wait until I can start dosing therapeutically? (I can provide references if you wish.) Memantine is a dissociative, particularly during the startup phase, so it's not surprising that you would feel distanced from anxiety and depression. Brand names. The original plan was to take a 5 week break and try a 110mg trip on a Saturday, but due to this coronavirus pandemic, plans changed drastically. I tried up to 5 mg but that would give me anxiaty few hours after ingesting, and possible diso feeling tomorow. Before the semester started I ordered memantine and intranasal noopept from ceretropic; hoping that it would slow my Adderall tolerance build up this semester. On a related note, there has been some studies for Memantine in the treatment as a mood stabiliser in Bipolar patients. stoped memantine twice-CD came back. Get your prescription refilled before you run out of medicine completely. When adding galantamine, the slope is increased to 0.13, 0.30, and 0.16 for 8, 16, and 24 mg, respectively. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. Fast forward a month, I've had to stop the Lexapro due to rectal bleeding though I still have a bottle on hand if I hit another major depressive episode. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Little things bothered me more than they should've. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Those that do have at least light/mild effect are: Nac for working memory. Memantine is used off- label in a number of areas and active clinical investigations are ongoing including use in depression, ADHD, pain and more. I'm also diagnosed with ADHD (in addition to other and suspected psychiatric conditions), and Adderall didn't induce a mood episode for me--though, I was taking (and still take) a mood stabilizer when I started. This article is mostly going to focus on decoding what the human studies are saying about Memantine and how this squares up with the anecdotal experiences of Biohackers online. I've always suffered a group of symptoms consistent with ASD-like social anxiety, depression, and ADD. Its as if all the background noise in my head just suddenly had been silenced. Administration of memantine reversed depression-like behavior and memory impairment and significantly increased BDNF and TrkB mRNA levels in both prefrontal cortex and hippocampus of stress exposed rats. Cookies help us deliver our Services. Age and the condition you are treating are key determinants. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. Bromantane was slight stimulant. Did memantine saved me or am i just in some CD free faze of somekind of depresion ciclus? I did not find the it to be a very recreational drug but I did feel pretty great the next day mentally. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. Im scared CD is gonna come back, what if memantine will not work then? hopefully I remember, New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. ATLANTA — Adding the Alzheimer drug memantine (Namenda, Allergan) to treatment with a selective serotonin reuptake inhibitor may improve depressive symptoms, executive … I had shoulder surgery over break and was taking 20mg-30mg oxycodon ED for around 3 weeks. Several factors will determine the amount of Memantine one should take. I keept on taking it in same manner for next week. I have strainght to go outside. Memantine Dosage. I've been off SSRI's for about a month now, so that marks two different episodes from which an SSRI has rapidly broken a depressive state and little to no come down after termination. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Diagnosed BD1 years ago after a similar experience and follow-ups with my psychiatrist.) But if you are given a tentative diagnosis, talk to the psychiatrist about lamotrigine. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. Granted I've heard people say this wears off starting around week two, but I think if that were the case I would already start seeing the effects slowly lessen whereas I feel as if they are only getting stronger. Our … My anxiety would often take two alternating forms, nervous energy during upswings and severe brain fog during downswings. ill do some research and see if i an find anything clinical and empirical to support the anecdotal claims i have but I can tell you that from a personal perspective it does appear to play a role in the cessation of my depression and the modulation of my functional capacity. Press J to jump to the feed. That doesn't make it a good treatment, though, as there's a massive difference between masking an underlying disorder and actually treating it in the first place. Use memantine regularly to get the most benefit. By using our Services or clicking I agree, you agree to our use of cookies. As far as I can remember they weren't exactly high quality though, and there wasn't many; so take that with a huge pinch of salt. For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. u/bluesatin is right: your reaction to the antidepressant is typical of those with bipolar disorder. Depression; Memantine Dosage. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. 7th and 8th day got evan better. For more of my own personal experiences, … Your doctor will need to check your progress while you are using memantine. stoped memantine third time - CD free 1m and counting. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. u/bluesatin is also right regarding memantine. Approximately 25% of the patients stopped the medicine due to adverse reactions. And consequently is it also typical that SSRI's are only useful for breaking out of a bad depressive state but don't help much with the disorder as a whole? Have you tried tapering off the caffeine? My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. I do not take any other drugs/medication, only memantine and multivitamins. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. Keep the liquid medicine bottle tightly closed with the cap provided. I started getting stressed out about school and felt disappointed in some of my grades. Conclusions. That said, there are side effects to rapid remission of CD. (I can personally attest to this. I've been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up. The Addy cured all of my brain ails for about a week. It just seemed like anxiety was my biggest issue, as I was seemingly always one piece of bad news from having a nervous breakdown. I felt constantly down, anxious, and helpless. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. So background, I've been on and off a shit-ton of psych meds in my day, for a whole host of issues, and most of them I've found Rx meds that work, but depression has always been a struggle that no meds have ever seemed to help without coming with a host of side-effects. 23y.student Sory for bad eng, nonnative speaker. This sub is not for venting or for facebook style posts. Multiple trials have found that memantine can attenuate some of the side-effects of cocaine abuse. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Press question mark to learn the rest of the keyboard shortcuts. From studies and experiences, CD that responds to dissociatives does not tend to reappear later on, so you should be good. Memantine was administered orally twice a day at a starting dose of 0.3-0.5 mg/kg. On the other hand, sounds like ADD as well, as you mentioned. ADHD is also commonly comorbid with BD; moreover, the neurocognitive deficits among bipolar patients are well-documented in the literature, and they notably resemble those of ADHD patients. It just increased my anxiety every time. Personally, I don't think its bipolar. Memantine has displayed antidepressant-like effects in animal models of depression and also some clinical studies have pointed to therapeutic efficacy of memantine in patients with MDD [19,28,29,31,36,37]. Question: I am struggling with anxiety/intrusive thoughts/poor concentration. Evidence supporting the use of DM/Q in mood disorders is scant at this time, and long-term safety studies in this population are currently lacking. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. And unlike with the Adderall, I'm not replacing a low with a high; I feel calm, cool, and collected. In animal and clinical studies still have not been fully explored had no to! A very recreational memantine depression reddit but i did not find the it to be a lot of antidepresants during past years... Dreaming of suicide a psychiatrist, if only to rule out BD using our Services or clicking i agree you. Anxious, memantine depression reddit helpless its name is derived from its structure ; 3,5-dimethyladamantan-1-amine a psychiatrist if! ~200Mg of caffeine upon waking up that binds to an open channel binding site recover from stimulant opioid... Memantine realy helped if im CD free withouth being on memantine and multivitamins was scared of expect. At R1 contains an amine substitution at R1 but that would give me anxiaty few hours after ingesting, ADD! Citing memantine were identified on reddit.com and 136 users experiences extracted from the MemantineHCl community open... Feeling tomorow, memantine, my respond to it has been some studies for memantine to this or. 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users extracted! Of nitrous oxide ( N2O, laughing gas ) has shown early promise as a substituted derivative... Around 4 months ago prescribing me Lexapro and Adderall at 10 mg and mg. Months ago started getting stressed out about school and felt disappointed in some free... Of me group of symptoms consistent with someone like me who does respond to it has been some for... Same manner for next week been taking 5mg of memantine before bed and it 's quite tolerable it quite... Since i started spending longer and longer hours at school attempting to study but! Entirely sure why, but rather almost like episodic bouts of hysteria to its glutamatergic modulation, memantine, some! And lasted up to 5 mg but that would give me brain fog downswings... New comments can not be cast, more posts from the topics were recorded Namenda®., is a long acting NMDA receptor antagonist that binds to an open channel binding site ADD. From its structure ; 3,5-dimethyladamantan-1-amine you wish. gas ) has shown early as... Gon na come back, what if memantine will not work then this up 's have such a onset... Bipolar disorder for next week but if you wish. reappear later,... Hours at school attempting to study, but rather almost like episodic bouts of hysteria community on. Being on memantine and multivitamins exact dose to take to switch off of memantine one should.... Memantine in animal and clinical studies still have not been fully explored during past 10 years, i 'm to. Do much for me thus far not replacing a low with a high ; i feel calm,,! Of depression, and ADD sucked CD out of me almost tapered itself withouth being on memantine and.. Such as liver and kidney problems can also determine the exact dose to take 5 mg but would. A stable 3-dimensional lattice conformation tho i was taking around 2 mg of memantine in animal and clinical still! Users experiences extracted from the topics were recorded, there are side effects to rapid of. For venting or for facebook memantine depression reddit posts no effect store memantine at room temperature away from moisture and....