r/MemantineHCl: A sub for discussing all uses of Memantine, from therapeutic to recreational. It is a miracle medicine. We took her off the medication and she is slowing gaining her speech and mobility back. More frequently reported side effects include: constipation, headache, and hypertension. But it isn't a fix-it-all for me. There are a number of reasons why memantine would be useful for dealing with opiate withdrawal. After taking only four pills she could not speak, could not move her legs, had no idea where she was. ... help Reddit App Reddit coins Reddit premium Reddit â¦ This information is NOT intended to endorse any particular medication. The neurologist prescribed Aricept which did not show much improvement but soon he decided to try memantine 5mg morning and night. If I avoid Nicotine, my withdrawals are much easier and last a shorter amount of time. Had to go back on Wellbutrin to stay awake. This is a generic drug. Diarrhea 5. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. And prescribed Dement (memantine). Mum has become very sleepy again so not sure if itâs the dementia or meds. Week 4/Maintenance Dose: 20 mg orally/day (Administer 10 mg twice a day.) Being able to understand nonverbal communication and verbal communication is huge improvements. He just passed away from surgery complications but after being off it he was NORMAL. MEMANTINE/N-METHYL-D-ASPARTATE (NMDA) ANTAGONISTS; Moderate Interactions. I am also prescribed clonidine and trazadone to help me with the withdrawal rituals. Does it have any effects on the nicotinic receptors? This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Week 3: 15 mg orally/day (Administer 5 mg and 10 mg as separate doses.) So, my brain is wired to experience these two substances together, so to speak. Patient was clearly getting better in fact even the recent memory was getting better, with the vitamins. The following information includes only the average doses of this medicine. My period is also now 9 days late and I know I'm not pregnant and I have never missed a period in my life. I always use Nicotine with my Opioids, and never just take one or the other. I don't know how long this will last, but I see a marked improvement.”. Constipation 3. I see no real positive effects. My heart goes out to every person who has to go through that, and their families as well.”, “My husband is the patient. Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Nothing short of a miracle. It came at the end of the year when insurance wouldn't pay for the drug. I have autism. For Alzheimerâs disease, doctors can prescribe a â¦ The memantine dosage will differ based on the use case. He does experience headaches and lightheadedness. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Are you certain Memantine won't have a Nicotine mimetic effect? Helps my cognitive functions Itâs been 2 months now and she is aware and able to go for walks by herself; dress herself and play the piano. Mum started answering the telephone, having conversations again . It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to perform daily functions. Consequently, there is a large pool of high-quality evidence that supports memantineâs use in moderate-to-severe cases of Alzheimerâs disease (AD). As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies. Not sure if there is any permanent damage from the drug yet but definitely will never let her take it again.”, Namenda (memantine) for Alzheimer's Disease: “Horrible drug! The med is fully working yet please give it another chance and more time. The memantine has been remarkable for his memory and parkinsons and how it has brought him back around, I am amazed at what all he remembers and just occasionally has a little problem.  Therapeutic doses (~10 mg) of memantine induced a mild altered state with cognitive stimulation and altered thought patterns with some parallels to low dose arylcyclohexylaminesâ¦ Head Pain I would also recommend NAC to inhibit overall glutamate overactivity during this time. And if you can get a hold of some, ibudilast is showing great promise for people with addictions due to its unique effect on microglial inflammation. We comply with the HONcode standard for trustworthy health information -, Drug class: miscellaneous central nervous system agents, Miscellaneous central nervous system agents. I don't abuse my friends and family, my anxiety is significantly lessened, and I can act normally in social situations. I have gone from having ~12 headaches a month to around 4 mild ones very quickly. Memantine is a prescription drug. During this time she regressed mentally. Not too many side effects to date. Namenda XR. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners. Memantine is available in various forms and doses. Thanks for the thorough reply. Take care and go up slowly on the memantine. But there will be a certain foggy headedness to it, due to its effect on nicotinic receptors. But if what you really wanted was reassurance that using Memantine while withdrawing from opiates is a good idea, then YES, absolutely it is. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This help me with social interaction. âI take 10mg memantine daily for mood instability related to bipolar disorder type 2. She's been taking Donepezil (Aricept) for about 5 years. The immediate-release tablets come in 10mg and 5mg. I am sure my nACh receptors are quite upregulated, but when I quit opoids, if I keep them upregulated (via Nicotine), I am absolutely miserable. I read reviews and it can be a mess just after a few days. So, my brain is wired to experience these two substances together, so to speak. I was able to have my mom back for two years until stroke. I suffer from chronic pain and the withdrawal is a conscious effort to help lower my tolerance to opioids. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice daily), 15 mg/day (5 mg and 10 mg as separate doses), and 20 Memantine is a game changer for me. No noticeable side effects. The dosing pump may only be used with the Memantine Hydrochloride 10mg/ml Oral solution in the bottle provided, not for other substances or containers. I'm 62 and thankful for this medication.”, Namenda (memantine) for Alzheimer's Disease: “Mother-in-law has Alzheimerâs and it was severe to where she went into a memory care. He is back over in his garden pottering about, he remembers all our names knows who he is again laughs tell jokes and has his little sarcastic humor back! The starting dose of 10mg made her very sleepy , after consulting with the geriatrician ( psychiatrist) it was increased to 15 mg and the changes were almost instant. But again, you've trampled on those by using nicotine for so long that it's really a moot point. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. While I am fairly confident that Memantine will help with opioid withdrawals from what I have read, I am more concerned with its "Nicotine mimetic effects". New comments cannot be posted and votes cannot be cast. When you first start taking this medication, you will usually take it once daily. She started it at stage 4. Seems to help my short term memory. And this has been a miracle drug! Comments: This drug should be initiated the day following the last dose of memantine and donepezil administered separately. I have tried a long list of supposed migraine prophylactic drugs over the last 15 years but none have worked for me. If your dose is different, do not change it unless your doctor tells you to do so. About 3 years ago he started having memory problems to the point of not remembering the day of the week or what he had just eaten. Not all pack sizes may be marketed. Once she started Namenda within second week it was like she was back to her old self. Not a full fix for me but huge help. I am more polite. Namenda, These mind altering drugs are BAD! Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. This medicine has given us more time with our loved one. It is taken by mouth. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 7. Causes mood swings.”, Namenda (memantine) for Alzheimer's Disease: “Three days in to this drug and find the condition worsening for mom dramatically”, For Alzheimer's Disease: “My father has been diagnosed with dementia he was gradually getting worse not recognizing us ( his adult children) and not sure which era he was in ( he is 92 years of age) then he started wandering on the road my mum was at her wits end looking after him. It did not rectify some of the mental losses, but she no longer experienced hallucinations (in jail; on a boat). No special requirements. But it has been 2 years since she started this medication. I started at 5 mg and titrated up to 10 mg after a week. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this backfired obviously. thank you to whoever made this drug”, For Alzheimer's Disease: “My mother-in-law was on Aricept for one year and could only take 5mg a day because anything over that caused night terrors. Learn more about Medicare prescription drug plans and savings with GoodRx. Sorry so many people have not been helped as he has but I can say Thank God it works great for him so far.”, Namenda (memantine) for Alzheimer's Disease: “My mother has taken aricept for 5 years. Not sure I would take it. Of course, it will be a different reaction for everyone; not everyone is the same. I'm glad I found this site to know that others have had problems too & it's not just me over thinking. They first prescribed Aricept, which caused nausea. Recently she has become very quiet and less chatty so the dose has been increased to 20mg. Memantine Accord 10 mg tablets are also available in perforated unit dose calendar blister in pack-sizes of 14x1, 28x1, 56x1 or 98x1 tablet. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multumâ¢ (updated 4 Dec 2020), â¦ Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fâ¦ It made me really dizzy, which I had already been struggling with after a concussion, and it made me feel drunk. Please everyone please give this medication time to work. donepezil, Aricept, Namenda, rivastigmine, vitamin e, Exelon. I think that this drug may help in the earlier stages. Then memantine is pulled into the channel to its binding site. I have researched the side affects and confusion is one of them. Once your dose increases to more than 5 milligrams per day, take this medication twice daily or as direâ¦ Asking the doctor 'what other drug may work'? It helps me in social interactions, I can recognize social cues and skills that I couldn't before! For Autism: “A life saver. In the middle she missed her pill for 1 week and her condition became worse like hallucinations, forgetting family members and not dressing properly. Press question mark to learn the rest of the keyboard shortcuts. My brain felt slow, my whole body felt heavy, and walking was really hard because of the dizziness. She was able to get up her her self dressed like she had did prior to the alzheimers. The first week on it he was sleepy and mean, but this subsided. So in a way it will only help you out. Confused 2. If experienced, these tend to have a Less Severe expression 1. But because it also antagonizes nicotinic receptors, you will lose a certain amount of overall dopaminergic tone, especially if you quit smoking at the same time. My mother was on the Exalon patch and my stepmother is on donepazil and memantine. So I waited for two weeks without drug to resume insurance at the first of the year. The extended release is better for the Alzheimer's patients. Mine does shortly up to the point I'm about to make as well, so no judgment. I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. I'm taking her off of it immediately.”, For Alzheimer's Disease: “I haven't experienced this firsthand but I've been researching this drug thoroughly, and I am conflicted with it's efficiency. Took 2.5mg to start off low today too see if it'll help. Memantine is a nicotinic antagonist, which from my limited understanding, both nicotinic Agonists (such as Nicotine) and nicotinic Antagonists (such as Memantine) both upregulate nicotinic receptors. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. My mother's confusion has amplified. Marketing authorisation holder. Usual Adult Dose for Alzheimer's Disease: IMMEDIATE-RELEASE: Week 1: 5 mg orally once a day. Dizzy 6. After 2 weeks, I've had to cut my adderall dose almost in half (from 25mg to 15mg) because 25mg is WAY too strong now. Literally after the first day of Namenda 20mg it was like someone turned the lights on. I can talk about others interest not just my needs or wants or questions that I had trouble asking. Unbelievable. If the pump does not function as described during intended use and according to instruction, the patient should consult the treating physician or a pharmacist. Press J to jump to the feed. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Although not all of these side effects may occur, if they do occur they may need medical attention. She was extremely agitated, angry and weepy. Helps me think And I don't know which is harder; treating for it and getting side effects, or not, and losing your memory. The dose of this medicine will be different for different patients. I've been on memantine for around 2 weeks now, started at 5mg and bumped up to 10 after a week. He has had Parkinsons about 10 years. It stops the intrusive thoughts, rumination, and repetitive thinking which is a Godsend. Work up to the maintenance dose. Helps my thought issue due to my autism and auditory processing disorder Also known as: She was active psychosis delusional, hallucinating 24/7. She had to go to the ER due to a subconjunctival hemorrage which was very scary! We are in Scotland so meds are free”, Namenda (memantine) for Alzheimer's Disease: “My sister has Moderate Frontal Lone Alzheimerâs. Last week her doctor said disease progressing too fast so put her on Memantine. His hallucinations have disappeared along with his garbled sentences. For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. Both the research  and anecdotal reports  recount as much. The dosage is based on your medical condition and response to treatment. Took some two other vitamins from a pharmacist for 3 months. It will not only help relieve withdrawal symptoms but it will help make less dope get you to your sweet spot, so to speak. Memantine needs to be researched extensively for the treatment of mood disorders. Memantine is great. She is doing well now. I am now at 15 mg for the last few weeks to see if I can get any further improvement. The extended-release is available in 28mg, 21mg, 14mg, and 7mg. Also using low dose Naltrexone daily. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. I wish you the best in your w/d man. Follow your doctor's orders or the directions on the label. I have no side effects that are apparent to me- a little burning in my legs for a few days when I increase the dose.”, For Alzheimer's Disease: “My dad was in advanced stage Alzheimer's, experiencing hallucinations and garbled sentence. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. What about just using NAC instead? The lowest GoodRx price for the most common version of memantine is around $14.20, 96% off the average retail price of $448.33. This drug should not be used!”, For Autism: “I take 10mg twice daily for autism spectrum disorder. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Thinking she is ready for a increase where she is getting her nighttime/early morning bad dreams back again. I'm really glad this medication works so well for so many people, but the side effects were too much for me to handle.”, For Autism: “I take 20mg of Memantine for my slight autism! Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. Nine of 11 studies included in the meta-analysis used Neuropsychiatric Inventory, 13 and the other two studies 14,15 used the Behavioral Pathology in Alzheimerâs Disease Rating Scale. Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. I always use Nicotine with my Opioids, and never just take one or the other. When it is working I can think clearly. Brand Names: Namenda, Namenda Titration Pak. Give it at least 2 weeks same time daily. Cough 4. It also helps with my obsessive and aggressive problems! Treatment should only be continued if beneficial effects are seen. As soon as I started it again, she improved-true testament. But if you have been an avid nicotine user for a long time, that upregulation you're speaking of has already essentially happened. After starting again she recovered. As with any drug, it may not work for others, but it was truly a God-send for my sweet mother. She was tired the first week but that was good rather to rest than to be awake delusional. Time will tell Week 2: 10 mg orally/day (Administer 5 mg twice a day.) Better behavior.”, Namenda (memantine) for Alzheimer's Disease: “My PCP put me on Namenda to supplement my Aricept for Alzheimer's Disease . amazing”, “I take 10mg memantine daily for mood instability related to bipolar disorder type 2. The side effects are really bad and requires additional medication. Memantine is used off- label in a number of areas and active clinical investigations are ongoing including use in depression, ADHD, pain and more. Finally, you can get a 360ml solution (2mg/ml). Broken shoulder then a broken wrist. He told us to reuse memantine and by the third day the negative side effects we were back. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. See below for a comprehensive list of adverse effects. It is insane to me that it is not more commonly used in non Alzheimer's conditions.”, For Alzheimer's Disease: “My mom started taking Memantine and after taking it for two weeks I believe this medication caused her to have very high blood pressure 220/110. Memantine Hcl Prices and Coupons. Patient forgets recent events and the doctor told us it was due to insufficient blood supply to the brain. 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